INTRODUCTION

Parasitic diseases are an important public health problem in India, where millions of people are infected with conditions such as malaria, soil-transmitted helminthiasis (STH), filariasis and others. Drug resistance, with incorrect use of anti-parasitic medications, provides fuel to these problems. As anti-Microbial resistance (AMR) is rising rapidly, to address this, anti-parasitic stewardship (APS) has emerged as an important strategy. This editorial provides an observation of the current status of APS in India, and emphasises performance, challenges and directions for the future.

PRESENT SCENARIO OF PARASITIC INFECTIONS IN INDIA

PARASITIC AMR: A CONCERN

Indiscriminate application of anti-parasitic medications has resulted in the development of resistance, making treatment regimens more complex and extending infection duration. In India, Chloroquine resistance in Plasmodium falciparum is around 99%, while sulfadoxine-pyrimethamine shows 42–51% resistance due to large-scale mutations; in contrast, artemisinin-based combination therapy remains highly effective7. Resistance to miltefosine among VL patients has also been observed in some areas of India8. Although Metronidazole remains effective in treating amoebiasis, there are reports of treatment failures and increased MICs, which may result in drug resistance. Similarly, resistance to nitroimidazoles in giardiasis is also being reported. Although drug resistance in other parasitic diseases has not been documented properly yet, inappropriate usage, such as self-medication and interrupted treatment courses, can enhance the development of resistance.

More importantly, parasitic AMR is less prevalent compared to bacterial/fungal AMR because:

·   Slower replication and smaller populations → fewer resistance mutations.

·   Rare horizontal gene transfer → limited spread of resistance traits.

·   Intermittent and combination drug exposure → less selective pressure.

·   Complex life cycles → reduced continuous drug pressure.

·   Limited surveillance/reporting → under-detection compared to bacteria/fungi.

The veterinary and agricultural application of anti-parasitic medications is a lesser-known generator of resistance among human parasites, especially in India, where human, animal, and environmental health infrastructure are highly connected. Ivermectin and albendazole are frequently used in veterinary animals to decrease gastrointestinal parasites as well as improve productivity. By 2023, the price of India’s veterinary parasitic market was around $ 288.4 million, and by 2030, it is estimated to reach $ 583.0 million, indicating a mixed annual growth rate of 10.6% from 2024 to 20309. The use of anti-parasitic agents is also seen in agriculture to control infestations due to nematodes in plants10.

Environmental contamination provides one of the most important routes along which resistance arises. Anti-parasitic residues find their way into soil and water environments through animal dung, farm runoff, and indiscriminate disposal of drugs11. These residues impose selective pressure on parasitic populations in the environment, leading to the survival of resistant genotypes. Humans can pick up these resistant strains through exposure to contaminated environments or from zoonotic transmission from animals in rural and peri-urban areas with inadequate sanitation12.

Cross-resistance in veterinary and human anti-parasitic has been reported as well. For instance, resistance of parasites in animals to albendazole has homologues among human soil-transmitted helminths10. Abuse of ivermectin in animal husbandry is likely to affect its effect in mass drug administration campaigns against onchocerciasis and lymphatic filariasis as well12.

ANTI-PARASITE STEWARDSHIP IN INDIA

The National Vector Borne Disease Control Programme (NVBDCP) has streamlined treatment procedures for malaria and VL and included drug resistance monitoring in national surveillance²,3,4. The use of rapid diagnostic tests (RDTs) has enhanced diagnostic accuracy and minimized empirical and improper usage of anti-parasitic drugs.

Public awareness campaigns like the Red Line Campaign, which aims to promote responsible use of antibiotics, including anti-parasitic medications, to fight against AMR and follow up with prescribed treatment13. APS principles [A1] have also been incorporated into medical education and continuing medical education (CME) for health professionals, with positive effects on responsible prescribing12.

CHALLENGES IN IMPLEMENTING ANTI-PARASITE STEWARDSHIP

Despite remarkable progress in APS, many important barriers still prevent its widespread application. One of the most important boundaries is the inaccessibility of an appropriate diagnostic facility in rural and remote areas. It leads to empiric treatment and abuse of parasitic medications from time to time13-15. Another challenge is the lack of surveillance systems for tracking resistance trends; it is difficult to identify resistant patterns and adjust the treatment guidelines accordingly14.

There is a lack of trained staff – especially parasitologists and pharmacologists who have a direct impact on the quality and sustainability of parasitic treatment. Another major problem is the over-the-counter availability of anti-parasitic drugs, which leads to irrational use. Regulatory problems also represent a major obstacle, as there is readily availability of over the counter anti parasitic medicine leads to irrational use of parasitic drugs. To ensure robust APS activity and sustainable parasitic disease control in India, it is imperative to remove these obstacles.

STRATEGIES TO ENHANCE ANTI-PARASITE STEWARDSHIP

India needs to implement a holistic and integrated APS principles. One of the priorities is to strengthen diagnostic strength by developing microscopy facilities along with efficiency, increasing the coverage of RDTs and molecular diagnosis tests for early and correct detection of parasitic infection. Concurrently, surveillance systems need to be fortified through the creation of strong regional and national databases that can track resistance patterns in diverse populations. This will aid in the development of dynamic, evidence-based policy recommendations.

Capacity development among health care providers is also a key element. Educating clinicians, pharmacists, and community health workers on the rational use of anti-parasitic drugs and the developing resistance patterns will enhance prescribing behaviour and minimise misuse. Reforms in regulations should also be made, such as enforcing prescription-only status for anti-parasitic drugs to prevent over-the-counter purchases and inappropriate self-medication. Community participation is central to stewardship.

Finally, the One Health strategy provides a comprehensive solution to combat parasitic resistance by accepting the mutual dependence of animal, human and environmental health. This encourages collaboration between doctors, veterinarians, farmers and environmental organisations to facilitate rational use of parasitic medicines in the areas. Resistance patterns in both human and animal populations should be traced by surveillance systems, and environmental pollution should be regulated through efficient waste management. Public awareness, regulatory reforms, and cross-sector cooperation are important to prevent abuse and secure drug efficiency.

CONCLUSIONS

Anti-parasitic stewardship is important for India’s plan to control parasite infections and maintain the effectiveness of anti-parasitic drugs. Although much has been achieved through the national initiative, consciousness production and revised guidelines, there are challenges in diagnosis, monitoring and the health care distribution. Long-term commitment, multi-sectoral collaboration and health care improvements are required to combat this obstacle. With a strong APS structure (Box 1[A2] ), India can increase the treatment effectiveness and protect the population from the new surge of parasitic diseases.

CONFLICTS OF INTEREST STATEMENT
The authors declare no conflict of interest. 

SOURCE OF FUNDING 

None 

DECLARATION FOR THE USE OF GENERATIVE ARTIFICIAL INTELLIGENCE (AI) IN SCIENTIFIC WRITING: NA

REFERENCES

1. 1. World Health Organization. World Malaria Report 2024. Geneva: WHO; 2024.[A2] 

   2. Khanna, V., Alur, S., Khanna, R., & Verma, S. (2024). A Comprehensive Review and Analysis of Intestinal Parasitic Infections in School Children from South India. Archives of Medicine and Health Sciences, 12(1), 78-81.

   3. Directorate of National Vector Borne Disease Control Programme (NVBDCP). Magnitude of disease: Lymphatic Filariasis. Ministry of Health and Family Welfare, Government of India. Updated 2023. Accessed May 12, 2025. Available from: https://nvbdcp.gov.in/index4.php?lang=1&level=0&linkid=431&lid=3713.

   4. National Vector Borne Disease Control Programme (NVBDCP). Kala-Azar Situation in India. Ministry of Health and Family Welfare, Government of India. Updated 2024. Accessed May 12, 2025. Available from: https://nvbdcp.gov.in/ka-annualreport.html

   5. Mital, A. K., Choudhary, P., & Jain, R. B. (2020). Prevalence and risk factors for neurocysticercosis in children with a first-onset seizure in rural North India. Paediatrics and International Child Health, 40(3), 158-165.

   6. Singh, S., Munawwar, A., Rao, S., Mehta, S., & Hazarika, N. K. (2014). Serologic prevalence of Toxoplasma gondii in Indian women of child bearing age and effects of social and environmental factors. PLoS neglected tropical diseases, 8(3), e2737.

   7. Sharma S, Verma A, Bhattacharya R. Drug resistance in malaria: A review. J Vector Borne Dis. 2019;56(1):1-10.

   8. Maltezou, H. C. (2010). Drug resistance in visceral leishmaniasis. BioMed Research International, 2010(1), 617521.

   9. Grand View Research. India Veterinary Parasiticides Market Size, Share & Trends Analysis Report by Animal Type (Production, Companion), by Product, by End-Use, by Region, and Segment Forecasts, 2024–2030. San Francisco, CA: Grand View Research; 2024. Accessed May 12, 2025. Available from: https://www.grandviewresearch.com/horizon/outlook/veterinary-parasiticides-market/india

   10. Boxall AB, Rudd MA, Brooks BW, et al. Pharmaceuticals and personal care products in the environment: what are the big questions? Environ Health Perspect. 2012;120(9):1221-1229.

   11. Taneja N, Sharma M. Antimicrobial resistance in the environment: The Indian scenario. Indian J Med Res. 2019;149(2):119-128.

   12. Roepstorff A, et al. Helminth infections in livestock and humans: diagnosis, prevention, and control. Vet Parasitol. 2011;180(1-2):3-17.[A3] 

   13. Ministry of Health and Family Welfare. Red Line Campaign: Promoting Rational Use of Medicines. Government of India; 2019.

   14. Ghosh K, Ghosh AR. Management of parasitic infections in India: Are we prepared? Trop Parasitol. 2020;10(1):1-6.[A4] 

   15. Picot, S., Beugnet, F., Leboucher, G., & Bienvenu, A. L. (2022). Drug resistant parasites and fungi from a one-health perspective: A global concern that needs transdisciplinary stewardship programs. One Health, 14, 100368.