SASPI Ltd.
Other specific DSP article suggested by Editorial Board
Early circulating biomarkers to predict plasma leakage in dengue fever
Citation:- 10.1016/j.jinf.2024.106400
Authors: Samaneh Moallemi et al., 2025
Highlights
* All patients with life threatening complications of dengue have plasma leakage as a preceding event.
* Early biomarkers for prediction of plasma leakage from well characterised prospective studies is scarce in dengue literature
* This study with prospective sample collection and outcome definition demonstrates that an early elevation of plasma VCAM-1 (vascular cell adhesion molecule-1) (OR:3.289, 95% CI: 1.090-9.926, p<0.05) and IL-33R (ST2) (interleukin 33 receptor) (OR: 2.677, 95% CI: 1.244-5.856, p<0.05) associated with subsequent plasma leakage.
* Elevated CCL11 (OR: 0.166, 95% CI: 0.057-0.483, p<0.05) was associated with a decreased risk. Notably, the protective role of CCL11 is a novel finding.
* These biomarkers are potentially useful to triage dengue patients on hospital admission to identify those at risk of plasma leaka
Other specific DSP article suggested by Editorial Board
Novel technologies for the diagnosis of urinary tract infections
Citation:- 10.1128/jcm.00306-24
Authors: Tomas Bermudez et al., 2025
Highlights
Urinary tract infections (UTIs) impose a substantial burden on patient quality of life and urine testing accounts for the majority of workload in many clinical microbiology laboratories. Traditional UTI diagnosis relies on symptoms, urinalysis, and culture which are interpreted based on historical guidelines. This approach, while foundational, presents limitations, particularly in complex cases. Low-level bacteriuria and the presence of fastidious organisms are often overlooked or entirely missed in standard urine culture, stressing the need for novel diagnostic methods and technologies. This mini-review summarizes the existing state of UTI diagnostics in 2024 and covers current and upcoming technologies including rapid molecular-based pathogen identification, next-generation sequencing, and advanced antimicrobial susceptibility testing. However, these methods represent unique challenges, and as they are implemented, they will require the field to adapt to new concepts to avoid misdiagnosis and overtreatment.